在患有自闭症和/或注意力缺陷/多动症障碍的儿童中,基于连接组的症状映射和in silico相关基因表达
Patricia Segura1,2, Marco Pagani1,3,4, Somer L Bishop5
1Child Mind Institute, New York, NY, USA.
Molecular psychiatry
|October 23, 2025
概括
自闭症和ADHD有着共同的生物学联系,特别是在中前回环和后带状皮层之间的大脑连接方面. 这种连接性与自闭症严重程度有关,表明共享的遗传机制.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 儿童精神病学 儿童精神病学
背景情况:
- 自闭症谱系障碍 (ASD) 和注意力缺陷/多动障碍 (ADHD) 呈现出显著的临床和遗传重叠.
- 了解共同的生物学基础对于开发有效的跨诊断干预至关重要.
研究的目的:
- 调查内在功能连接 (iFC) 与儿童ASD和ADHD症状的维度测量之间的关联.
- 探索这些神经发育条件背后的共同遗传机制.
主要方法:
- 使用全大脑多变量距离矩阵回归对166名口头儿童 (6-12岁) 的IFC数据进行了分析,这些儿童被诊断为ASD或ADHD.
- 通过临床观察评估ASD症状,通过家长采访评估ADHD症状.
- 在基因表达分析中进行基因表达分析,以确定相关的遗传模式.
主要成果:
- 发现自闭症症状严重程度和左中额头 (额头对面网络) 和后侧带带皮层 (默认模式网络) 之间的iFC之间存在显著的跨诊断关联.
- 这些区域之间的更高的IFC与自闭症症状严重程度的增加相关,独立于ADHD评级.
- 对于ADHD症状,没有观察到有意义的脑行为关系.
- 基因丰富分析涉及的基因涉及神经元投射和那些在ASD和ADHD的高变异.
结论:
- 该研究强调了互联网连接的重要性,特别是在前端对面和默认模式网络之间,在自闭症症状的表现中.
- 研究结果表明,共同的遗传机制有助于在ASD和ADHD中观察到的大脑行为表型.
- 强调跨诊断的价值,在连接临床表现生物机制在宏观电路和基因组层面的维度方法.
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