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Updated: Jan 6, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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表观遗传原始化促进了对氨酸激酶抑制剂的耐药性和基因放大

Rebecca M Starble1,2,3, Eric G Sun1,2,4, Rana Gbyli1,2

  • 1Department of Genetics, Yale School of Medicine, New Haven, CT, USA.

Nature structural & molecular biology
|October 23, 2025
PubMed
概括

瘤基因放大驱动肺腺癌 (LUAD) 中对氨酸激酶抑制剂 (TKI) 的耐药性. 一种叫做METTL7A的蛋白质重塑色素,使基因放大和TKI耐药性成为可能,提供了一个新的治疗点.

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