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Updated: Jan 14, 2026

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表达MEF2D的癌症前体重编程组织寄存的巨细胞,以支持肝脏瘤发生

Junyu Xiang1,2, Yuanli Ni1, Jiajun Yu1,3

  • 1Center for Precision Medicine of Cancer, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital and Chongqing University School of Medicine, Chongqing, China.

Nature cancer
|October 23, 2025
PubMed
概括

癌症前体通过调节MEF2D来重编程肝脏巨细胞 (Kupffer细胞),从而创造出支持生长的微环境. 准NRP1信号阻止了这种重编程,抑制了肝脏瘤发生,并提供了早期癌症预防的策略.

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