关于SARS-CoV-2/DENV联合感染的教训和担忧
Camila Moreira Andrade1, Ana Cláudia Arantes Marquez Pajuaba1, Cristina Rostkowska1
1Laboratory of Immunoparasitology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG, 39405-307, Brazil.
巴西面临着登革热和SARS-CoV-2的双重爆发. 这项研究发现COVID-19病例明显低估,增加了严重结果的风险,特别是登革热的共感染.
科学领域:
- * * 公共卫生 公共卫生
- * 传染病 传染病
- * 流行病学 流行病学
背景情况:
- *巴西有登革热流行病的历史,受到COVID-19大流行严重影响.
- *同时爆发的登革热和SARS-CoV-2疫情对公共卫生系统构成重大威胁.
- * 了解共感染动态对于管理公共卫生危机至关重要.
研究的目的:
- * 为了确定巴西Minas Gerais的登革热症状患者的SARS-CoV-2血清阳性.
- *分析在COVID-19大流行初期之前和期间的病毒感染趋势.
- * 评估SARS-CoV-2感染的潜在低估情况.
主要方法:
- *回顾性队列研究分析了2019年1月至2021年4月的2969个血清样本.
- *用登革热IgM捕获ELISA测试样本以检测登革热.
- *使用COVID-19 IgG/IgM快速测试设备检测到SARS-CoV-2感染.
主要成果:
- *SARS-CoV-2阳性样本最终数量超过登革热阳性样本.
- *这项研究表明,在此期间,SARS-CoV-2感染的数量被严重低估.
- *观察到独立的病毒感染,没有直接的因果关系.
结论:
- *SARS-CoV-2的真实发病率可能高于报告,增加了严重的COVID-19风险.
- * 同时感染登革热可能会加剧严重COVID-19结局的风险.
- *公共卫生战略需要考虑并发性病毒流行病和潜在的不足诊断.
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