鲁米诺科克斯 (Ruminococcus torques) 通过调节肠道微生物群和胆酸代谢来改善炎症性肠道疾病和肠道屏障功能障碍
Yue Lou1, Yao Lv1, Xiaoxi Wang1
1Gastroenterology Department, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Child Health, Hangzhou, 310052, China.
Journal of translational medicine
|October 24, 2025
概括
肠道细菌Ruminococcus torques在儿童炎症性肠病 (IBD) 中显示出治疗潜力. 在小鼠模型中补充R.扭矩可以通过改善肠道屏障功能和减少炎症来减少结肠炎.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 儿童炎症性肠病 (IBD) 缺乏特征的微生物特征,以获得独特的肠道营养 (EEN) 疗效.
- 识别保护性微生物群及其机制对于儿童有针对性的益生菌发育至关重要.
研究的目的:
- 确定儿童IBD中EEN疗效的微生物决定因素.
- 研究候选保护性菌株的治疗潜力和机制.
主要方法:
- 儿童克罗恩病 (CD) 患者的便微生物群与健康对照组 (HC) 的比较.
- 分析了元基因组数据,进行了qPCR和胆酸 (BA) 分析.
- 使用大肠炎 (DSS和TNBS) 的小鼠模型来测试R.扭矩补充.
主要成果:
- 鲁米诺科克 (R. torques) 的扭矩在活跃的CD中被耗尽,并在EEN后恢复.
- R.扭矩的丰度与疾病严重程度有负相关,与BA比率有正相关.
- 在小鼠中补充R. torques可以减少结肠炎,增强上皮质完整性,抑制炎症,调节BA代谢和自.
结论:
- 鲁米诺科克 (Ruminococcus torques) 是IBD的潜在微生物治疗候选者.
- 机制包括调节BA平衡,增强上皮屏障和解决炎症.
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