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细颗粒物质空气污染和反核抗体

Naizhuo Zhao¹, Audrey Smargiassi², Hong Chen³

¹Center for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

Rheumatology (Oxford, England)

|October 24, 2025

概括

暴露于细颗粒物 (p.m.2.5) 与较高的抗核抗体 (ANA) 水平有关. 这表明空气污染可能会影响系统免疫力,可能会增加自身免疫性疾病的风险.

科学领域:

环境健康环境健康
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

空气污染,特别是细颗粒物 (p.m.2.5),越来越多地与系统性自身免疫性风湿性疾病 (SARD) 相关.
关于p.m.2.5暴露与SARDs的血清生物标志物之间的联系的研究有限.

研究的目的:

在一般人群群中调查环境p.m.2.5暴露与反核抗体 (ANA) 之间的关联.
为了确定p.m.2.5暴露是否与增加的ANA标位相关.

主要方法:

来自安大略省健康研究的3548名参与者的血清样本被分析为ANA标位.
估计了每年平均p.m.2.5水平,并根据住宅邮政编码进行了分配.
使用多变量逻辑回归模型来评估对混因子调整后的ANA阳性概率.

主要成果:

较高的p.m.2.5暴露四分位数与高ANA标位的几率增加有关 (≥1:640和≥1:1280).
对于ANA标度≥1:640和≥1:1280的几率比率分别为1.46和1.54,在比较最高和最低的p.m.2.5暴露四分位数时.
观察到一个连续的关联,增加pm2.5暴露与较高的ANA标题相关,尽管置信区间通常包括较低标题的统一性.

结论:

环境p.m.2.5暴露与ANA阳性有关,特别是在高位数时.
这些发现支持了p.m.2.5暴露可以诱导全身免疫效应的假设.
需要进一步的研究来了解将空气污染与自身免疫反应联系在一起的机制.

关键词:

空气污染空气污染自免疫性类风湿性疾病.流行病学流行病学血清生物标志物是血清生物标志物.

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