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终端基因通过1,2-C/Pd (II) /PIDA启用的迁移性三重功能化,通过1,2-C/Pd (IV) 双向性重新排列

Chen-Xu Liu¹, Qian Wang¹, Jieping Zhu¹

¹Laboratory of Synthesis and Natural Products (LSPN), Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, Lausanne, 1015, Switzerland.

Angewandte Chemie (International ed. in English)

|October 24, 2025

概括

这项研究引入了一种新的催化反应,用于基功能化. 这一过程通过形成新的碳-碳和碳-氧键,产生了有价值的1,3-oxazine化合物.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
合成方法论合成方法论

背景情况:

的催化对于现代有机合成至关重要.
使用高价试剂的氧化转化已经得到了很好的证实.
双向型重组为分子构造提供了独特的途径.

研究的目的:

开发一种新的Pd(II) 催化终端基的迁移性三重功能化.
为了合成6 - 乙氧化5,6-二-4H-1,3-oxazines.
阐明反应机制,包括Pd (II) /Pd (IV) 催化循环和二极管重组.

主要方法:

使用 (II) 催化与同质胺和 (III) 乙酸 (PIDA).
通过机理学研究来研究反应途径.
描述由此产生的1,3-oxazine产品.

主要成果:

实现了终端基的新的Pd(II) 催化迁移三重功能化.
在一个步骤中合成了6-乙化5,6-二-4H-1,3-oxazines.
该机制涉及氧化化,Pd(II) 到Pd(IV) 氧化,以及1,2-基 (基) /Pd(IV) 双基重组.

结论:

在Pd(II) /Pd(IV) 系统中报告的二极管重排是前所未有的.
这种转化为功能化的1,3-oxazines提供了一条新的合成途径.
这项研究扩大了催化氧化转换的范围.

关键词:

双向型重组的重新排列方式不同周期的异质环.高价值的是高价值的.氧化化是指一种氧化化.这就是PIDA PIDA.

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