孕期孕产妇营养及其与后代性别的关联:使用日本环境和儿童研究数据的前性队列研究
Rie Matsushita1, Sachiko Tanaka-Mizuno1,2, Misaki Nakahata1
1Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, https://ror.org/02kpeqv85Kyoto University, Kyoto, Japan.
Journal of developmental origins of health and disease
|October 24, 2025
概括
怀孕期间母亲的饮食没有显示出与后代性别的总体联系. 然而,特定的营养摄入量和母亲的年龄可能会影响胎儿的性别确定,这表明需要进一步的研究.
科学领域:
- 生殖生物学 生殖生物学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 孕期前期母亲的营养对于胎儿的发育至关重要.
- 母亲饮食对后代性别决定的具体影响尚不清楚.
- 了解这些关联可以为生殖健康策略提供信息.
研究的目的:
- 调查母亲在怀孕期间的营养摄入量与后代的性别之间的联系.
- 分析宏观营养素,脂肪酸及其比例对后代性别的影响.
- 探索母亲年龄,能量摄入量和对后代性别的营养影响之间的潜在相互作用.
主要方法:
- 利用了来自日本环境和儿童研究的数据,包括97510对母婴对.
- 分析了母亲摄入脂肪,蛋白质和脂肪酸与后代性别之间的联系.
- 在统计分析中调整了母亲的人口统计和生活方式因素.
主要成果:
- 在母亲摄入总脂肪酸,和脂肪酸,多不和脂肪酸,n-3PUFA,n-6PUFA,蛋白质或特定比率 (n-6/n-3,SFA/能量) 和后代的性别之间没有发现一致的总体关联.
- 在高能量摄入量 (≥4,000 kcal/day) 的母亲中,较高的残留蛋白摄入量与男性出生率的增加相关 (aOR,1.87).
- 在年轻的母亲 (<20岁) 中,增加n-3PUFA摄入量与更高的男性出生几率有关,而更高的n-6/n-3比率与更低的男性出生几率有关.
- 在20-35岁的母亲中,较高的n-3PUFA摄入量与男性出生率降低有关 (aOR,0.89).
结论:
- 虽然没有普遍的联系,但特定的母亲营养模式,特别是与母亲年龄相关的能量和脂肪酸摄入量,可能会影响后代的性别.
- 这些发现突出了母亲的饮食,年龄和生殖结果之间的复杂相互作用.
- 需要进一步的研究来阐明这些细微关联背后的机制及其对生殖健康的影响.
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