中性粒细胞与淋巴细胞的比率与免疫球蛋白脏病患者的早期功能下降之间的关联
Cun Shen1, Mengchao Liu1, Zhen Cai1
1Department of Nephropathy, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Annals of medicine
|October 24, 2025
概括
较高的中性细胞与淋巴细胞比率 (NLR) 表明IgA脏病 (IgAN) 患者功能下降的风险更大. 这项研究发现高NLR独立地与Igan估计膜过率 (eGFR) 的降低有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- IgA脏病 (IgAN) 是一种渐进的自身免疫性脏疾病.
- 中性细胞对淋巴细胞的比率 (NLR) 是系统性炎症的新兴指标.
- 了解NLR在IGAN进展中的作用对于早期干预至关重要.
研究的目的:
- 为了研究NLR和Igan患者早期功能下降之间的关联.
- 为了确定NLR是否可以预测IGAN中减少的估计膜过率 (eGFR).
- 评估与 IgAN 中高 NLR 相关的临床表现.
主要方法:
- 一项对1073名Igan患者进行的横截面观察研究.
- 分为高和低NLR组的分层.
- 对eGFR,ROC曲线和后勤回归进行分析,以评估NLR对eGFR≤60mL/min·1.73m2的预测值.
主要成果:
- 具有eGFR≤60mL/min·1.73m2的患者的NLR水平显著更高 (p<0.001).
- 高的NLR独立地与降低的eGFR相关 (OR = 2.110,p = 0.009).
- 高NLR组表现出更差的临床参数,包括高血压和蛋白尿.
结论:
- 升高的NLR与IgAN中更严重的临床表现有关.
- 在IgAN患者中,高的NLR可以作为降低功能 (eGFR ≤60mL/min·1.73m2) 的预测标记.
- 进一步的研究可以探索NLR在IGAN管理中的治疗影响.
相关概念视频
Nephrotic Syndrome I : Introduction
493
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
493
Factors Affecting Renal Clearance: Renal Impairment
420
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
420
Nephrotic Syndrome II : Assessment and Medical Management
197
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
197
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
233
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
233
Serum Studies: Renal Function Tests
361
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
361
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
188
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
188


