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Updated: Jan 14, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
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WNT3A Upregulates RIP1/HIF-1α/GDF-15路径诱导EMT,从而增加结肠直肠癌细胞迁移和入侵

A-Ram Kang1, Tae-Jun Kim1, Jung-Yoon Yoo2

  • 1Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.

Cancer research and treatment
|October 24, 2025
PubMed
概括

这项研究揭示了一个新的WNT3A信号通路,涉及RIP1,HIF-1α和GDF-15,驱动着结直肠癌 (CRC) 细胞迁移和入侵. 针对这一轴可以为转移性CRC提供新的治疗策略.

关键词:
结直肠瘤是什么意思在EMT中,EMT是EMT.这是GDF-15的GDF-15.在RIP1的过程中,没有信号通道.

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