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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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相关实验视频

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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

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解码信号架构:固体瘤免疫治疗中的CAR与TCR动态.

Zui Chen1,2, Xin Zhou1,2

  • 1School of Basic Medicine, Capital Medical University, Beijing 100069, China.

Acta biochimica et biophysica Sinica
|October 24, 2025
PubMed
概括

化学抗原受体 (CAR) -T细胞疗法通过通过新的工程策略克服诸如不良透和免疫抑制等障碍,对固体瘤具有前景. 这些进展旨在改善固体恶性瘤患者的治疗结果.

科学领域:

  • 免疫学 免疫学 免疫学
  • 癌症生物学 癌症生物学
  • 生物技术是生物技术.

背景情况:

  • T细胞受体 (TCR) 信号传递对T细胞激活至关重要.
  • 化学抗原受体 (CAR) -T细胞疗法在血液恶性瘤中取得了成功,但在固体瘤中面临挑战.

研究的目的:

  • 为了总结CAR信号的动态.
  • 突出突破性策略,以提高CAR-T细胞在固体瘤中的疗效.

主要方法:

  • 审查目前对CAR信号的理解.
  • 对CAR-T细胞的新型工程策略的分析.

主要成果:

  • 固体瘤存在障碍,包括透不良,免疫抑制性瘤微环境 (TME),代谢竞争和抗原异质性.
  • 策略包括工程CAR用于增强信号,细胞因子分泌,表观遗传重编程和合成生物学方法.

结论:

  • 最近的进展正在缩小CAR-T细胞治疗液体和固体瘤之间的疗效差距.
  • 这些策略有望改善临床结果和固体恶性瘤的个性化免疫治疗.
关键词:
在CART-T中,我们可以使用CAR-T.在TCR中,可以使用TCR.免疫疗法 免疫疗法固体瘤是一个固体瘤.

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