在类风湿性关节炎中客观测量的睡眠障碍及其与疾病活动的关联
Patricia Katz1, Sarah L Patterson1, Mary C Nakamura2
1University of California San Francisco, San Francisco, CA.
Arthritis care & research
|October 24, 2025
概括
睡眠不足在类风湿性关节炎 (RA) 中很常见. 客观测量表明经常出现睡眠问题,包括睡眠效率低和睡眠呼吸暂停,与较高的RA疾病活动有关.
科学领域:
- 类风湿病学 类风湿病学
- 睡眠医学 睡眠医学
- 临床研究 临床研究
背景情况:
- 自我报告的睡眠障碍在风湿性关节炎 (RA) 患者中很普遍.
- 对RA的客观睡眠研究有限,这阻碍了对睡眠质量及其影响的理解.
研究的目的:
- 确定RA患者客观测量的睡眠特征的流行率.
- 调查客观睡眠参数与RA疾病活动之间的关联.
主要方法:
- 长度研究使用动图来测量睡眠效率 (SE),入睡后清醒时间 (WASO) 和总睡眠时间 (TST).
- 观察PAT设备通过呼吸暂停指数 (AHI) 评估睡眠呼吸障碍 (SDB),包括阻塞性睡眠呼吸暂停 (OSA).
- 使用临床疾病活动指数 (CDAI) 和疾病活动指数 (DAS) 测量了RA疾病活性.
主要成果:
- 在多个测量期内,超过40%的RA患者表现出不良的SE (<85%).
- 用WatchPAT评估的半数以上的参与者患有中度至重度OSA (AHI≥15).
- 较低的SE和较高的WASO与增加的RA疾病活性相关 (CDAI,DAScrp,DASesr); AHI也与CDAI和DAScrp相关.
结论:
- 客观测量的睡眠问题,包括睡眠效率低下和OSA,在RA中很常见.
- 这些睡眠障碍与较高的RA疾病活动有显著的关联.
- 建议在RA患者中增加对睡眠障碍的临床关注,因为它们对健康有负面影响.
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