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可改变的生活方式和结直肠多的代谢风险因素:系统性审查和元分析

Yue Lei¹, Zihong Cai¹, Mengli Zheng¹

¹Department of Big Data in Health Science, and Center for Clinical Big Data and Statistics, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Frontiers in public health

|October 24, 2025

概括

不健康的生活方式,如吸烟和高脂肪饮食,以及代谢状况,如2型糖尿病,显著增加结直肠的风险. 吸烟对聚合体亚型和区域产生不同的影响.

科学领域:

胃肠病学胃肠病学
公共卫生公共卫生
在瘤学瘤学.

背景情况:

结肠直肠多是结肠直肠癌的前体,需要识别可修改的危险因素.
生活方式和代谢因素都与多胞体的发展有关,但亚型特定的关联需要进一步阐明.

研究的目的:

评估不健康的生活方式,代谢疾病和结肠直肠多之间的关联.
强调这些风险因素对多体发育的亚型特异性影响.

主要方法:

在PubMed,Embase,Cochrane图书馆和SinoMed的系统文献搜索到2024年7月.
使用随机效应模型进行元分析,以量化与生活方式和代谢因素相关的结直肠多瘤的几率比率 (OR).
使用子组,元回归,灵敏度分析和漏斗图来评估异质性,效果修改和出版偏差.

主要成果:

酒精 (OR=1.63),高脂肪饮食 (OR=1.45) 和吸烟 (OR=1.79) 显著增加了聚合体的风险.
吸烟对状状病变 (SSLs;OR=3.06) 的风险最高,因地区而异 (美国,韩国,以色列).
2型糖尿病 (OR=2.17),高脂血症 (OR=1.50) 和高血压 (OR=1.33) 与多风险的增加有显著关联.

结论:

不健康的生活方式和代谢疾病独立地增加结直肠多风险.
吸烟具有显著的亚型和区域风险差异,特别是在SSLs.
这些发现支持风险分层查和针对性公共卫生干预措施,以预防结直肠多.

关键词:

结肠直肠多体是一种多体.生活方式生活方式进行元分析.病理类型病理类型有关风险因素的风险因素.

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