关于诊断和治疗上衣细胞淋巴瘤的 EHA-EU MCL 网络指南
Mats Jerkeman1,2, Igor Aurer3, Elias Campo4
1Department of Oncology Skåne University Hospital Lund Sweden.
HemaSphere
|October 24, 2025
概括
膜细胞淋巴瘤 (MCL) 治疗正在超越传统免疫化学疗法. 新型药物,如共价布鲁顿氨酸激酶抑制剂 (cBTKi),有望改善MCL患者的治疗结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 薄膜细胞淋巴瘤 (MCL) 是一种罕见的B细胞淋巴瘤,临床行为可变.
- 诸如增殖率和TP53突变等风险因素会影响MCL的攻击性.
- 患者经常出现需要全身治疗的扩散性疾病.
研究的目的:
- 为MCL诊断,分期,治疗和随访提供基于证据的建议.
- 审查MCL不断变化的治疗环境,包括新型治疗剂.
- 为管理MCL患者的临床实践提供指导.
主要方法:
- 对MCL的现有证据和临床实践指南的审查.
- 对免疫化学疗法和新药治疗结果的分析.
- 对复发性或耐火性MCL新兴疗法的评估.
主要成果:
- 免疫化疗仍然是标准的,但新型药物,特别是共价布鲁顿氨酸激酶抑制剂 (cBTKi),正在改善结果.
- 对于老年患者,非化疗选择如rituximab加cBTKi正在出现.
- 复发性/耐药性MCL的快速发展的选择包括CAR-T细胞疗法,新型BTK抑制剂,BCL2抑制剂和T细胞参与剂.
结论:
- 治疗MCL正在转向将新药与传统化疗一起或代替传统化疗.
- 管理MCL需要根据患者年龄,疾病阶段和风险因素量身定制的方法.
- 持续的研究和指南更新对于优化MCL患者护理至关重要.
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