与肥胖相关的微生物失生症作为瘤进展的潜在调节器
Omar Mokhashi1,2, Jaideep Chakladar1,2,3, Wei Tse Li1,2,4
1Department of Otolaryngology-Head and Neck, University of California, San Diego, La Jolla, CA 92093, USA.
Access microbiology
|October 24, 2025
概括
与肥胖相关的肠道微生物通过影响细胞信号和炎症来影响癌症的进展. 特定的细菌与体重指数 (BMI) 相对应,并影响患者的存活率,提供新的精准医学目标.
科学领域:
- 微生物组研究的研究.
- 癌症生物学 癌症生物学
- 肥胖研究的研究.
背景情况:
- 肥胖是已知的癌症风险因素,但机制尚不清楚.
- 肠道微生物组的改变与肥胖有关.
- 需要阐明微生物在与肥胖相关的癌症进展中的作用.
研究的目的:
- 研究与肥胖相关的肠道微生物组变化与癌症进展之间的联系.
- 为了确定与体重指数 (BMI) 和癌症途径相关的特定微生物.
- 探索微生物对瘤信号,炎症和患者预后的影响.
主要方法:
- 从肥胖和癌症患者的组织样本中分析微生物丰富度.
- 微生物物种与体重指数 (BMI) 的相关性.
- 微生物与癌症相关的信号通路和基因表达的关联.
主要成果:
- 已识别的与BMI相关的微生物 (例如*Pseudomonas fluorescens*,*Lactobacillus sakei*) 与支持和抗瘤原生效应有关.
- 在肥胖和癌症组织中发现了丰富的微生物 (例如, * Pseudomonas baetica *) 与上调的瘤性途径相关.
- 观察到与BMI相关的微生物,化学激素信号传递,TFR2/NFkB基因和患者存活率之间的相关性.
结论:
- 与肥胖相关的肠道微生物组失调与癌症的发展和进展有关.
- 特定的微生物影响癌症预后和患者的生存率.
- 这些发现表明,在癌症治疗中,基于微生物组的精准医学有可能发挥作用.
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