在老年和非老年患者之间的全身麻醉诱导期间,BIS<60的雷米马佐拉姆有效镇静剂量-一个随机对照试验
Jun-Li Zheng1,2, Jie-Feng Sun2,3, Qing Han1,2
1Department of Anesthesiology, The first People's Hospital of Lin-ping District, Hangzhou, Zhejiang, China.
Frontiers in pharmacology
|October 24, 2025
概括
这项研究确定了在接受日间手术的老年和非老年患者的全身麻醉中使用雷米马佐拉姆的有效剂量. 与非老年患者 (ED95:0.418 mg/kg) 相比,老年患者需要较低的雷马佐拉姆剂量 (ED95:0.336 mg/kg).
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 老年医学 老年医学
背景情况:
- 对于日间手术的老年和非老年患者的瑞马佐拉姆与sufentanil的有效剂量存在有限的研究.
- 一般麻醉需要精确的镇静剂定位,以获得最佳的患者结果.
研究的目的:
- 估计雷马佐拉姆的95%有效剂量 (ED95) 达到双光谱指数 (BIS) 分数低于60.
- 为了比较Remimazolam ED95在老年和非老年患者之间,这些患者接受了低剂量sufentanil的妇科日间手术.
主要方法:
- 一项前性研究,涉及100名接受选择性妇科日间手术的患者.
- 患者被随机分配到四个雷米马佐拉姆剂量组 (0.1-0.4毫克/千克),用固定的苏芬坦尼尔剂量 (0.1微克/千克).
- 成功镇静被定义为BIS<60在5分钟内;计算ED50和ED95.
主要成果:
- 预计雷米马佐拉姆的ED95为老年患者的0.336毫克/千克 (95% CI:0.286-0.437) 和非老年患者的0.418毫克/千克 (95% CI:0.361-0.528).
- 老年患者的低血压率显著增加 (P<0.05).
- 两组之间没有观察到胸或呼吸抑制的显著差异.
结论:
- 在白天手术中,Remimazolam与0.1μg/kg sufentanil用于BIS<60整体麻醉的ED95在老年患者 (0.336 mg/kg) 中低于非老年患者 (0.418 mg/kg).
- 年龄是影响雷米马佐拉姆在全身麻醉中剂量要求的重要因素.
- 在接受雷米马佐拉姆和苏芬坦尼尔的老年患者中,仔细监测低血压至关重要.
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