血清微量营养素与高级CKM综合征之间的关联:可解释的基于机器学习的研究
Yi Ou1, Xinyi Shao1, Yidian Fu2
1Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China.
Food science & nutrition
|October 24, 2025
概括
低水平的关键微量营养素,包括维生素D (25(OH) D),维生素C和甘,与晚期心血管和病综合征 (CKM) 的更高风险有关. 管理这些营养水平可能有助于控制这种情况.
科学领域:
- 心血管和脏医学 心血管和脏医学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 心血管和脏疾病 (CKM) 是一种常见的系统性疾病,涉及复杂的心血管相互作用.
- 血清微量营养素与晚期CKM综合征之间的联系仍然不太清楚.
- 微量营养素摄入量越来越多地被认为与心血管疾病 (CVD) 和慢性病 (CKD) 有潜在的关联.
研究的目的:
- 调查血清微量营养素水平与晚期CKM综合征风险之间的关联.
- 确定特定的微量营养素,这些微量营养素可以作为高级CKM综合征的预测生物标志物.
- 探索微量营养素在晚期CKM综合征的病因和管理中的潜在作用.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 采用Boruta算法进行血清微量营养素特征选择.
- 使用7个机器学习 (ML) 模型预测的高级CKM综合征风险,包括LGBM.
- 应用SHAP和PDP分析来解释ML模型的预测并评估微量营养素的影响.
主要成果:
- 低血清水平的β-胡卜素,α-托哥菲醇,甘,维生素C和25(OH) D显著与晚期CKM综合征的风险增加有关 (p <0.05).
- 该LGBM模型在预测高级CKM综合征风险方面表现出卓越的表现.
- 在SHAP和PDP分析中,低25OH) D水平被确定为主要的危险因素,25OH) D,维生素C和柳科有协同作用.
结论:
- 这项研究使用先进的ML技术为血清微量营养素与高级CKM综合征风险之间的关系提供了新的见解.
- 降低25-OH-D,烯和维生素C的水平被确定为晚期CKM综合征的关键潜在风险因素.
- 控制血清中25-OH-D,维生素C和烯的水平可能对控制晚期CKM综合征和为公共卫生战略提供信息至关重要.
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