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母亲花生摄入量和母乳养时间对后代DNA甲基化的影响

Jessica L Garay¹, Margaret A Voss¹, Stefanie R Pilkay²

¹Department of Nutrition and Food Studies Syracuse University Syracuse New York USA.

Food science & nutrition

|October 24, 2025

概括

怀孕期间母亲的花生摄入量可能会改变母乳养时间对后代的影响.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
营养神经科学营养神经科学
发展生物学发展生物学

背景情况:

母亲的饮食影响后代的表观遗传学,影响神经发育和炎症.
关联母亲饮食,表观遗传学和儿童发育的机制需要进一步阐明.

研究的目的:

研究母亲的花生摄入量如何影响母乳养时间,收入,种族和儿童神经发育和炎症基因的DNA甲基化之间的关系.
探索早期生命发展中的基因环境相互作用.

主要方法:

在35名2-7岁儿童的唾液DNA甲基化分析.
关于母亲饮食 (怀孕/母乳养),母乳养时间,收入和儿童种族的家长问卷.
对DNA甲基化模式的统计分析与母亲的花生摄入量和人口因素相关.

主要成果:

孕妇在怀孕期间摄入花生/花生可能会使BDNF基因对母乳养时间敏感,观察到不同的DNA甲基化模式.
收入与BDNF DNA甲基化的相互作用因母乳养期间的花生消费而有所不同.
观察到IL6-AS1DNA甲基化的种族/种族差异,取决于孕妇在怀孕期间的花生摄入量.

结论:

孕妇在怀孕和母乳养期间食用花生可以改变对母乳养时间,收入和种族的表观遗传反应.
这些发现突出了母亲营养,表观遗传学和儿童发育之间的复杂相互作用.
需要进一步的研究来了解这些饮食-表观遗传相互作用的长期影响.

关键词:

大脑衍生的神经营养因子饮食饮食饮食饮食表观遗传学是指表观遗传学.基因表达的基因表达方式这是一种炎症炎症炎症炎症.互白素-6 的作用.怀孕怀孕怀孕怀孕怀孕

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