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炎症性肠病中的Th17/Treg不平衡:免疫机制和微生物群驱动的调节
Yuyuan Hu1, Yuhang Yang1, Yan Li2
1Division of Colorectal Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Frontiers in immunology
|October 24, 2025
概括
炎症性肠病 (IBD) 涉及由Th17和调节性T (Treg) 细胞之间的不平衡驱动的肠道炎症. 恢复肠道微生物群平衡是调节这种免疫反应以有效治疗IBD的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,以慢性肠道炎症为标志.
- 免疫失调,特别是涉及T-辅助17 (Th17) 和调节性T (Treg) 细胞,是IBD病原体的核心.
- 偏好促炎的Th17细胞而不是抗炎的Treg细胞的不平衡加剧了IBD的肠道炎症.
研究的目的:
- 审查肠道微生物群在IBD中调节Th17/Treg细胞平衡中的作用.
- 探索针对IBD治疗的Th17/Treg轴的治疗策略.
主要方法:
- 文献综述总结了关于IBD,免疫细胞和肠道微生物群的当前研究.
- 对研究肠道失生症对Th17和Treg细胞功能的影响进行分析.
- 检查旨在恢复IBD免疫恒温的治疗干预措施.
主要成果:
- 肠道失生症通过促进Th17细胞活性和损害Treg细胞功能来促进IBD.
- 通过益生菌,饮食或移植恢复肠道微生物群平衡可以改善免疫反应.
- 调节Th17/Treg平衡对控制IBD症状和进展有希望.
结论:
- 肠道微生物群显著影响Th17/Treg细胞平衡,影响IBD免疫反应.
- 针对这种平衡的治疗策略,包括细胞因子抗剂和免疫抑制剂,为IBD提供了新的治疗途径.
- 了解肠道微生物群和免疫细胞之间的相互作用对于开发有效的IBD疗法至关重要.
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