免疫辅助型流感疫苗在患有1型糖尿病的儿童中的免疫性在连续两个赛季内
Mikhail Petrovich Kostinov1,2, Maria Alexandrovna Kvasova3, Alla Anatolievna Tarasova3
1Ivan Mikhailovich I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Frontiers in immunology
|October 24, 2025
概括
患有1型糖尿病 (T1D) 的儿童对三价流感疫苗表现出强烈的免疫反应,符合免疫性标准. 这种流感疫苗有效保护患有T1D的儿童免受严重疾病的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病患者患有严重流感和并发症的风险增加.
- 接种流感疫苗对于患有1型糖尿病 (T1D) 等慢性疾病的人来说至关重要.
- 了解儿童T1D群体的疫苗免疫性对于公共卫生战略至关重要.
研究的目的:
- 在患有T1D的儿童中评估三价抗体免疫辅助子单元流感疫苗的免疫性.
- 为了评估抗体反应和持续在两个连续的流感季节.
- 确定疫苗是否符合该脆弱人群中确定的免疫性标准.
主要方法:
- 一项前性非随机研究包括146名患有T1D的儿童 (12.0岁).
- 81名儿童接种了三价流感疫苗;65人作为未接种疫苗的对照.
- 使用血凝抑制试验测量了抗体水平,疫苗接种前,1个月和疫苗接种后12个月.
主要成果:
- 接种疫苗的儿童在接种疫苗后一个月内,对所有三种疫苗菌株的抗体显著增加.
- 接种疫苗显著增加了获得A/H1N1,A/H3N2和B菌株保护性抗体水平的可能性.
- 抗体持久性因菌株而异;B菌株的持久性最高,而A/H3N2的持久性在各组之间没有显著差异.
结论:
- 三价免疫辅助子单元流感疫苗有效诱导T1D儿童接种疫苗后抗体的形成.
- 该疫苗符合专利制药委员会 (CPMP) 的免疫性标准.
- 疫苗接种史没有影响疫苗在这个队列中达到免疫性标准的能力.
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