喘中的免疫和炎症机制:对表观遗传修饰的洞察
Haixia Fan1, Bomeng Zhao2, Huiyan Niu2
1First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in immunology
|October 24, 2025
概括
表观遗传学在喘发育中起着至关重要的作用,影响免疫反应和基因调节. 本文献分析揭示了关键的研究领域,并强调了喘精准医学中表观遗传疗法的必要性.
科学领域:
- * 呼吸系统医学 呼吸系统医学
- * 免疫学 免疫学
- *遗传学和表观遗传学
背景情况:
- *喘是一种慢性呼吸道疾病,具有复杂的遗传和环境影响.
- *表观遗传学越来越被认为是喘病变的关键调节因素.
- * 了解免疫-表观遗传相互作用对于喘研究至关重要.
研究的目的:
- *系统地审查和综合有关喘免疫-表观遗传机制的现有证据.
- * 通过参考文献分析,识别喘表观遗传学的全球研究趋势,关键贡献者和新兴热点.
主要方法:
- *对Web of Science核心集合 (WoSCC) 和Scopus数据库 (1980年至2025年7月) 的系统文献搜索.
- *使用CiteSpace,VOSviewer和R bibliometrix包对4020个出版物的分析.
- *评估出版趋势,国家/机构/作者生产力,期刊影响力和关键词的同时出现.
主要成果:
- *自2010年以来,喘表观遗传学的研究显著增长,美国和中国是主要贡献者.
- * 关键机构 (哈佛大学,加州大学系统) 和作者 (Adcock,Celedón,Barnes) 的识别.
- *确定了四个主要的研究热点:免疫机制,表观遗传调节,基因环境相互作用和表观遗传疗法/生物标志物.
结论:
- * 喘表观遗传学研究正在迅速扩大,国际合作也在不断增长.
- *未来的研究应该优先将表观遗传发现转化为临床应用.
- *专注于生物标志物验证,患者分层,以及开发基于表观遗传的喘疗法.
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