富里埃转换多个实例学习整个幻灯片图像分类
Anthony Bilic1, Guangyu Sun1, Ming Li1
1Institute of Artificial Intelligence (IAI), Center for Research in Computer Vision, Orlando, Florida, United States.
Journal of medical imaging (Bellingham, Wash.)
|October 24, 2025
概括
富里埃变换多个实例学习 (FFT-MIL) 通过频域分析结合全球上下文来增强整个幻灯片图像的分类. 这种方法可以提高计算病理学的诊断准确性.
科学领域:
- 计算病理学计算病理学
- 数字病理学数字病理学
- 医疗图像分析 医学图像分析
背景情况:
- 全幻灯片图像 (WSI) 分类通常使用多个实例学习 (MIL) 与空间补丁功能.
- 目前的MIL方法在捕捉全球依赖性方面面临挑战,原因是WSI大小和本地补丁嵌入,限制了用于诊断的粗结构建模.
研究的目的:
- 引入富里埃转换多个实例学习 (FFT-MIL),这是一个新的框架,旨在将全球背景整合到WSI分类中.
- 通过结合频域信息来解决现有的MIL方法在模拟粗结构方面的局限性.
主要方法:
- FFT-MIL通过使用快速里埃转换 (FFT) 的频域分支来增强标准的MIL,以从WSIs中提取低频作物.
- 一个模块化的FT-Block,具有卷积层和Min-Max规范化,处理这些频率作物以生成紧的全球上下文.
- 学习的全球频率特征通过与各种MIL架构兼容的轻量级集成策略与空间补丁特征融合.
主要成果:
- 通过将FFT-Block集成到三个公共数据集 (BRACS,LUAD,IMP) 的六种最先进的MIL方法中来评估FFT-MIL.
- 在不同架构和数据集中,整合使宏观F1得分平均提高了3.51%,曲线下的面积提高了1.51% .
结论:
- FFT-MIL证明了频域学习在捕捉WSI分类中的全球依赖性的有效性.
- 这种方法补充了空间特征,提高了基于MIL的计算病理学的可扩展性和准确性.
- 该研究为FT-MIL提供了一个公开可用的代码库,促进进一步的研究和应用.
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