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优化对疑似IBD紧急转诊的分类:来自伯明翰IBD发病研究的结果

Peter Rimmer^1,2, Jonathan Cheesbrough^1,2, Jane Harris²

¹Birmingham NIHR Biomedical Research Centre in Inflammation, University of Birmingham, Birmingham, UK.

Frontline gastroenterology

|October 24, 2025

概括

通过将症状史与便calprotectin (FCP) 检测相结合,可以改善早期炎症性肠病 (IBD) 的诊断. 一个单个升高的FCP结果可以准确预测IBD,简化患者护理.

科学领域:

胃肠病学胃肠病学
临床诊断临床诊断临床诊断
炎症性肠道疾病研究研究

背景情况:

炎症性肠病 (IBD) 的诊断延迟导致患者的负面结果.
在管理疑似IBD病例时,有效的资源利用至关重要.

研究的目的:

开发和评估一个综合临床病史和便calprotectin (FCP) 的诊断途径,用于早期IBD检测.
优化IBD诊断中的资源配置.

主要方法:

在紧急转诊标准之外,为疑似IBD患者实施快速访问途径.
根据症状和初始FCP水平进行分离,然后进行详细的症状史和前性数据收集,包括重复FCP.
分析诊断预测因素和连续FCP测量的准确性.

主要成果:

在767名患者中,423人被诊断患有IBD (208名克罗恩氏病,215名性结肠炎).
IBD的主要预测因素包括血液与便混合以及体重减轻.
一次重复的FCP水平≥220μg/g在预测IBD方面显示出高准确度 (AUC0.923),优于双值策略.
将症状评估与FCP建模结合,进一步提高了预测准确度 (AUC 0.947).

结论:

连续的FCP测量可以有效地防止不必要的结肠镜检查.
单次升高的FCP结果 (≥220μg/g) 是IBD的强烈预测因素.
将家庭FCP测试与症状评估相结合,为有效的自我转诊途径提供了基础,改善了早期诊断和资源管理.

关键词:

克罗恩氏病 (CROHN'S DISEASE) 是一种疾病.在临床上,IBD是IBD.炎症性肠病炎症性肠病这是一个不好的结合.

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