一个类固醇依赖的免疫检查点抑制剂肺炎病例,用皮下托西利祖马巴治疗
Nicole Chang1, Alexa Meara2, Kevin Ho3
1Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus Ohio USA.
Respirology case reports
|October 24, 2025
概括
这项案例研究强调了皮下托西利祖马布作为一种新型治疗类固醇依赖免疫检查点抑制性肺炎 (ICI-p) 的新疗法. 它提供了一种方便的家庭选择,用于管理癌症免疫治疗的严重副作用.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制性肺炎 (ICI-p) 是与癌症免疫治疗相关的严重不良事件.
- 类固醇治疗是ICI-p的标准治疗方法,但类固醇依赖的病例需要长时间的治疗,并可能导致显著的副作用.
- 对于患有复发性或类固醇依赖性ICI-p的患者,需要选择替代治疗方案.
研究的目的:
- 报告第一例使用皮下托西利祖马布治疗类固醇依赖性免疫检查点抑制性肺炎 (ICI-p) 的病例.
- 评估托西利祖马布在治疗尿道癌患者的ICI-p治疗中的疗效和安全性.
- 评估皮下注射的潜力,以提高患者的舒适性和减少治疗负担.
主要方法:
- 一名患有尿路癌的57岁男性,尽管接受了类固醇治疗,但却出现了复发性ICI-p.
- 患者接受了静脉注射,随后是皮下托西利祖马布,用于类固醇依赖的ICI-p.
- 监测了治疗结果,包括ICI-p分辨率,类固醇断奶,副作用概况和癌症状况.
主要成果:
- 托西利祖马布治疗导致ICI-p的持续消失.
- 患者成功地戒掉了类固醇,体验了类固醇相关副作用的改善.
- 在治疗期间,根本的膀癌没有进展或复发.
结论:
- 皮下托西利祖马布是一种可行的和有效的治疗选择,用于类固醇依赖的ICI-p.
- 这种方法可以减少长期使用类固醇和相关毒性的需要.
- 在家用皮下施用托西利祖马布为管理ICI-p提供了一个方便的替代方案.
相关概念视频
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
COPD: Management Using Bronchodilators and Corticosteroids
722
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
722
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
483
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
483
Cytotoxic T Cells-mediated Immune Response
6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.5K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.5K
Chronic Obstructive Pulmonary Disease-V: Management
3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.1K


