产生GABA的乳球菌可缓解与易怒肠综合征相关的肠道功能障碍和神经行为异常
Zhiying Jin1,2, Mengyu Chen1,2, Lanxi Ao1,2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu, China.
Microbiome research reports
|October 24, 2025
概括
生产胺黄油酸 (GABA) 的乳球球菌株有效治疗小鼠易肠综合征 (IBS) 症状. 这些益生菌通过调节肠道和大脑中的GABA信号来改善肠道健康并减少焦虑.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 刺激性肠综合征 (IBS) 的特点是肠道功能障碍和神经行为异常.
- GABAergic信号传递在肠道功能和中枢神经系统活动中起着至关重要的作用.
- 调节GABA水平为IBS提供了一个潜在的治疗策略.
研究的目的:
- 为了选乳糖菌株的甘氨基黄油酸 (GABA) 产量.
- 为了评估GABA产生的乳球菌乳糖在刺激性肠综合征 (IBS) 鼠标模型中的有效性.
- 调查涉及GABAergic信号传递和剂量依赖效应的潜在机制.
主要方法:
- 根据GABA产量和遗传分析选择了三种Lactococcus lactis菌株.
- 使用Citrobacter rodentium感染和避免水的压力在小鼠中诱导IBS.
- 对肠道完整性,炎症,组织病理学,行为和GABAergic信号标记物的评估.
主要成果:
- 在IBS小鼠中,产生GABA的菌株显著缓解了肠道功能障碍和类似焦虑的行为.
- 治疗以剂量依赖的方式调高了结肠GABA水平,GABRA13 mRNA和GABRA3蛋白表达.
- 在肠道和中枢神经系统 (包括海马和杏仁体) 观察到增强的GABAergic信号传递.
结论:
- 产生GABA的乳糖菌有效地改善与IBS相关的肠道和神经行为问题.
- 治疗效果是由肠-大脑轴中GABAergic信号的协调调节介导的.
- 在多种IBS表型中观察到的改善的基础上有一个明确的剂量依赖机制.
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