在2型糖尿病中连接心脏和大脑:全球纵向应变与认知功能之间的关联
Federica Barutta1, Alessandro Andreis1,2,3, Martina Bollati1
1Department of Medical Sciences, University of Turin, Turin, Italy.
Frontiers in endocrinology
|October 24, 2025
概括
全球纵向应变 (GLS) 损伤,这是衡量心脏功能的指标,与2型糖尿病 (T2DM) 患者的认知能力下降有关. 这种关联即使在正常的左心室喷射分数下也持续存在,突出显示GLS是T2DM认知衰退的潜在指标.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 认知障碍是2型糖尿病 (T2DM) 的常见并发症.
- 全球纵向菌株 (GLS) 表明亚临床左心室缩功能障碍,与T2DM的心血管结果有关.
- 在T2DM患者中,GLS和认知表现之间的关系尚不清楚.
研究的目的:
- 为了研究GLS和T2DM患者的认知功能之间的联系.
- 确定GLS是否是T2DM认知障碍的独立预测因素.
主要方法:
- 预计将招募234名T2DM患者,这些患者没有显著的动脉狭窄,中风病史或严重的低血糖症.
- 使用可重复电池评估神经心理状态 (RBANS) 评估认知功能.
- 通过斑点跟踪回声心脏学测量GLS;用于分析的多变量线性回归.
主要成果:
- 19.7%的患者有边缘性/受损认知 (RBANS 分数<80).
- 29.1%的人表现出亚临床 LV 功能障碍 (GLS ≥-18%).
- 即使在调整和排除后,受损的GLS与较低的RBANS分数独立相关,并且在受教育程度较低的人群中更为明显.
结论:
- 损坏的GLS独立地与T2DM患者的认知能力下降有关.
- 在T2DM中,GLS可以作为认知衰退的标志物,无论左心室喷射分数如何.
- 对T2DM中心脏功能障碍和认知障碍之间的机制进行进一步的研究是有必要的.
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