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LINC00917通过准miR-491-5p/FOXP4轴促进乳腺癌的骨转移

Xin Qu¹, Cao Wang¹, Ying Xu¹

¹The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, 650118, People's Republic of China.

Breast cancer (Dove Medical Press)

|October 24, 2025

概括

长非编码RNA LINC00917通过准miR-491-5p.p.促进乳腺癌骨转移. LINC00917的上调与预后不佳有关,并通过miR-491-5p/FOXP4轴促进转移.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳腺癌是女性癌症死亡的主要原因之一.
骨转移显著恶化患者的预后和生活质量.
确定乳腺癌骨转移的新型分子点至关重要.

研究的目的:

研究LINC00917在乳腺癌骨转移中的作用.
探索LINC00917和miR-491-5p之间的监管关系.
为了确定LINC00917是否可以作为乳腺癌患者的预后标志物.

主要方法:

用RT-qPCR量化254名乳腺癌患者的LINC00917水平.
卡普兰-梅尔和考克斯回归分析用于预后评估.
在体外测试 (CCK-8,Transwell) 和双露西法酶记者测试以阐明分子机制.

主要成果:

在转移性乳腺癌组织中,LINC00917的表达显著上调,并与预后不佳有关.
击败LINC00917抑制了癌细胞功能,抑制了骨质细胞生成,并促进了骨质细胞分化.
抑制MiR-491-5p逆转了LINC00917敲击的效果,这表明了一个调节轴.

结论:

LINC00917是乳腺癌骨转移的潜在预后生物标志物.
通过调节miR-491-5p/FOXP4通路,LINC00917促进骨转移.
准LINC00917可能为预防乳腺癌骨转移提供治疗策略.

关键词:

现在我们来看看LINC0091717的情况.骨转移的发生.乳腺癌乳腺癌乳腺癌在 miR-491-5p 中.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...