低频波动的异常幅度和功能连接在患有原发性经期障碍的患者
Zili Zhu1,2, Feirong Xu3, Guotian Hu1,2
1The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Frontiers in integrative neuroscience
|October 24, 2025
概括
原发性经期障碍 (PD) 患者在默认模式网络 (DMN) 中显示出大脑活动的改变,特别是低频波动 (ALFF) 和功能连接 (FC) 的振幅降低. 这些变化可能有助于区分PD患者与健康个体.
科学领域:
- 神经成像是一种神经成像.
- 临床神经科学 临床神经科学
- 妇女健康 妇女健康
背景情况:
- 初级经期障碍 (PD) 是一种常见的妇科疾病,与严重的疼痛和潜在的情绪困扰有关.
- 默认模式网络 (DMN) 在自我参考处理和情绪调节中起着至关重要的作用,其功能障碍已与各种临床条件有关.
- 了解PD的神经基础,特别是大脑活动的改变,对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究原发性失经症 (PD) 患者在默认模式网络 (DMN) 中自发性大脑活动的改变.
- 与健康对照者相比,检查PD患者的DMN中低频波动 (ALFF) 和功能连接 (FC) 幅度的变化.
- 探索DMN活动变化与PD患者情绪调节之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于14名PD患者和24名健康对照 (HC).
- 进行了低频波动幅度 (ALFF) 和功能连接 (FC) 分析,以评估DMN活动.
- 对9名PD患者进行了神经心理尺度,以将大脑活动与情绪调节相关联.
主要成果:
- 与HC相比,PD患者在左侧中环,极和上环中显著减少了ALFF.
- 在PD患者中,在极和右上额头 (SFG),背侧补充运动区域 (SMA) 和前中心之间观察到降低的FC.
- 一个趋势表明,在PD患者中,ALFF值和焦虑水平之间存在正相关性.
结论:
- 原发性失经症与DMN内的多维功能大脑变化有关.
- ALFF和FC分析揭示了PD患者大脑活动的不同模式.
- 这些神经成像标记物显示出作为敏感生物标记物的潜力,可以将PD患者与健康个体区分开来.
关键词:
低频波动 (ALFF) 的幅度默认模式网络 (DMN) 是一个默认模式网络.功能连接 (FC) 的功能连接 (FC)原发性经期障碍 (Dysmenorrhea) 是一个主要的疾病.静止状态的功能磁共振成像技术更多相关视频
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