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使用NULISAseq和血p-tau217进行阿尔茨海默病病期分期的多变量模型

James D Doecke¹, Edwin Stage², Christopher Fowler³

¹Australian E-Health Research Centre, CSIRO, Herston, Queensland, Australia.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|October 24, 2025

概括

血-tau217 (p-tau217) 显示出对阿尔茨海默氏症的治疗有希望.

科学领域:

神经退行性疾病神经退行性疾病
生物标志物发现发现
阿尔茨海默氏症疾病的诊断方法

背景情况:

血-tau217 (p-tau217) 在预测粉样β (Aβ) 阳性方面表现出很高的性能,与脑脊液 (CSF) 生物标志物相当.
虽然血p-tau217提供了确认的Aβ状态信息,但对于各种阿尔茨海默病 (AD) 阶段的最佳血液生物标志物 (BBM) 需要进一步调查.

研究的目的:

为了比较单个p-tau217测定与多生物标志物面板的预测性表现,以确定阿尔茨海默病 (AD) 的阶段.
为了评估额外的血基生物标志物 (BBM) 的实用性,超越p-tau217来评估AD进展.

主要方法:

利用了来自澳大利亚成像,生物标志物和生活方式研究的387名参与者的数据.
评估参与者使用[18F]NAV4694 (Aβ) 和[18F]MK-6240 (tau) PET扫描.
使用ALZpath和Lumipulse测定测量了血p-tau217,并通过Alamar Biosciences NULISASeq平台分析了370种蛋白质 (中枢神经系统和炎症).

主要成果:

多变体血基生物标志物 (BBM) 模型在预测阿尔茨海默病 (AD) 阶段时显著超过了单个p-tau217测定.
与ALZpath试验相比,Lumipulse p-tau217试验在区分疾病阶段方面表现优越.
多变量BBM模型对疾病分期的预测准确性 (曲线下的面积) 比独立的p-tau217试验更高,特别是在早期阶段.

结论:

将p-tau217与额外的BBM结合在一起,可以对不同AD阶段的整体疾病负担提供宝贵的见解.
与单个生物标志物方法相比,多变量BBM模型为AD诊断和分期提供了增强的预测能力.
Lumipulse测定是一种比ALZpath测定更有效的p-tau217测定,用于区分AD阶段.

关键词:

阿尔茨海默病的疾病阿尔茨海默病的疾病.贝塔氨基化物贝塔氨基化物生物分期生物分期血生物标志物的生物标志物预测预测预测预测知道的知道的知道的

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