预防性抗生素与细胞癌患者的剥离后感染之间的关联:回顾性多中心队列研究
Qian Cai1,2, Ran Ji2, Mengjuan Mu2
1Clinical Medical School, Qinghai University, Qinghai, China.
International journal of surgery (London, England)
|October 24, 2025
概括
预防性抗生素在细胞癌切除后不需要常规使用. 然而,患有较大的瘤的糖尿病患者可能会从它们的使用中受益,以减少不严重的感染.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 预防性抗生素在细胞癌 (RCC) 切除后预防感染的必要性是不确定的.
- 这项研究旨在评估预防性抗生素在降低移除后感染率方面的疗效,并确定可能受益的特定患者群体.
研究的目的:
- 为了确定预防性抗生素是否会降低T1a RCC的皮肤穿透热移除后的感染率.
- 确定可能从预防性抗生素使用中受益的患者子组.
主要方法:
- 对895名T1a RCC患者进行了回顾性,多中心的队列研究,这些患者接受了穿皮热切除除.
- 使用治疗权重的逆概率 (IPTW) 和重叠权重 (OW) 的预防性抗生素 (PA) 和非预防性抗生素 (nPA) 组的比较.
- 主要结局:感染 (严重/不严重);次要结局:住院时间,费用,发烧和急性损伤 (AKI).
主要成果:
- 在调整后,PA组 (1.8%) 与nPA组 (3.7%) 的整体感染率较低.
- 严重感染率在各组之间没有显著差异 (0.4%对1.1%).
- 抗胰岛素组经历了更长的住院时间,更高的成本和更高的AKI发病率.
- 患有3-4厘米瘤的糖尿病患者显示,预防性抗生素的非严重感染率降低 (P的相互作用=0.02).
结论:
- 常规预防性抗生素的使用不推用于皮肤间的RCC切除.
- 预防性抗生素可以考虑用于特定的患者亚组,特别是糖尿病患者,其瘤大小为3-4厘米.
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