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脂质分析揭示了糖尿病风险中的性别差异:对精准医学的影响

Ana F Pina^1,2, Maria João Meneses^1,3, Fabrizia Carli⁴

¹iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon, Portugal.

European journal of clinical investigation

|October 24, 2025

概括

独特的胰岛素机制和脂质概况显示了糖尿病前期的性别差异,识别了患糖尿病并发症风险较高的个体. 了解这些代谢表型是个性化风险评估的关键.

科学领域:

代谢性疾病研究研究.
内分泌学在内分泌学.
利皮多米克 (Lipidomics) 是一种消化剂.

背景情况:

2型糖尿病 (T2D) 是一种复杂的疾病,具有显著的并发症.
了解性别特定的代谢差异对于预测T2D风险和并发症至关重要.

研究的目的:

调查不同的胰岛素衍生机制和脂质配置文件是否区分T2D并发症的基于性别的风险.
确定与患糖尿病相关并发症风险更高的表型.

主要方法:

在PREVADIAB2研究中,在最初没有T2D的个体中,分析了5年内的代谢变化.
基于胰岛素生成指数 (IGI),胰岛素分泌率,HOMA-IR和胰岛素清除,用于分层953名参与者的等级分类.
用LC/MS-QTOF对488名参与者的子集进行了脂质组分析.

主要成果:

确定了四个不同的集群:肝敏感 (LS),胰腺葡萄糖敏感 (PGS),胰岛素缺乏 (ID) 和胰岛素抵抗 (IR),每个都有独特的失糖症风险.
虽然核心代谢特征在两性之间是相似的,但参数值和脂质组状况显示出明显的性别差异.
女性表现出较高的二基胺和基胺 (SM),表明脂质代谢发生变化,而男性的基胺与SM比率较高.

结论:

与胰岛素相关的不同代谢特征和性别有助于形成具有独特脂质组特征的不同表型.
这些发现强调了在糖尿病前期管理中考虑葡萄糖以外的更广泛的代谢背景的重要性.
性别特定的脂质样本与代谢功能障碍有关,并可能改进糖尿病并发症的风险分层.

关键词:

聚类集群是指聚类的聚类.糖尿病糖尿病患者糖尿病患者代谢不良的情况.异质性的异质性脂质组的类型是什么

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