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夜班工作是否与卵巢癌有关? 一个系统的审查和元分析

Ahmed Arafa^1,2, Mazin Alhussein³, Amin Alayyan⁴

¹Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Osaka, Japan.

Medical sciences (Basel, Switzerland)

|October 24, 2025

概括

夜班工作可能会增加卵巢癌的风险,特别是在病例对照研究中. 需要进一步的研究,以在大型前性研究中证实这一关联.

科学领域:

流行病学流行病学
职业健康职业健康职业健康
在瘤学瘤学.

背景情况:

夜班工作是可能的致癌物,原因是昼夜节律受到干扰.
夜班工作与卵巢癌风险之间的联系尚未得到充分证实.
这项研究调查了夜班工作与卵巢癌之间的关联.

研究的目的:

系统地审查和分析关于夜班工作和卵巢癌的现有研究.
为了确定夜班工作是否与卵巢癌的风险增加有关.
探索以前研究中不一致的潜在原因.

主要方法:

在2025年6月之前,对多个数据库进行系统的文献搜索.
使用随机效应模型计算概率比率 (OR) 和95%置信区间 (CI) 的聚合效应估计.
使用I2统计和出版偏差评估异质,使用埃格尔回归测试和漏斗图.

主要成果:

包括七项研究 (八个队列),涉及超过250万名女性.
总体而言,夜班工作与卵巢癌没有显著的关联 (OR = 1.13; 95% CI: 0.96, 1.32).
在病例控制研究 (OR = 1.36; 95% CI: 1.12, 1.66) 和高质量研究 (OR = 1.17; 95% CI: 1.00, 1.37) 中发现了显著的关联.

结论:

虽然整体结果并不显著,但病例控制研究表明,夜班工作者卵巢癌风险增加.
在一些队列研究中,暴露的错误分类可能使风险估计减弱.
需要进行更大规模的前性研究,并进行详细的暴露评估,以确认这些发现.

关键词:

预防癌症预防癌症流行病学证据流行病学证据这是一个元分析.晚班的工作人员在夜班工作.职业风险 - 职业风险是什么卵巢癌是发生在卵巢的癌症.系统性审查系统性审查

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