2型糖尿病的亚临床心肌功能障碍:从左心室透气功能和全球纵向应变评估的见解
Thao Phuong Nghiem1, Hoang Minh Tran2, Dung Ngoc Quynh Nguyen3
1Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 7000, Vietnam.
Medical sciences (Basel, Switzerland)
|October 24, 2025
概括
亚临床心肌功能障碍在2型糖尿病 (T2DM) 患者中常见,患者的喷射分数保持. 使用全球纵向菌株 (GLS) 早期检测可以帮助心血管风险管理.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 在2型糖尿病 (T2DM) 中的糖尿病心肌病症往往是无声的.
- 早期发现左心室 (LV) 功能障碍对于预防心力衰竭至关重要.
- 这项研究侧重于T2DM患者的保留喷射分数 (EF).
研究的目的:
- 在2型糖尿病患者中评估LV透功能障碍和全球纵向应变 (GLS) 损伤的患病率,并保持EF.
- 在这个人群中确定与心肌功能障碍相关的危险因素.
- 加强早期检测和心血管风险管理策略.
主要方法:
- 对232名T2DM和EF>50%的成年人进行横截面研究.
- 利用横胸和斑点跟踪回声心脏图谱来评估LV透静功能和GLS.
- 采用后勤回归来确定心肌功能障碍的预测因素.
主要成果:
- 在53.9%的患者中观察到LV静脉动态功能障碍.
- 在13.4%的患者中检测到GLS损伤.
- 独立预测因素包括年龄≥60岁,糖尿病持续时间 (5-10年),男性性别,以及透缩功能障碍的存在.
结论:
- 亚临床心肌功能障碍在越南T2DM患者中普遍存在,EF保留.
- 扩张功能障碍和降低的GLS可以独立或同时发生.
- 将GLS整合到心声回声学中可以改善早期检测和量身定制的风险管理.
相关概念视频
01:30Cardiomyopathy II: Dilated Cardiomyopathy
464
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
464
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
399
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
399
01:29Heart Failure II: Pathophysiology
707
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
707
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
215
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
215
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
449
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
449
01:22Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K