基于检查清单的药物不良反应在急诊室患者的识别
Benjamin J Hellinger1,2,3, Thilo Bertsche3,4, Yvonne Remane2,3
1Emergency Department/Observation Unit Leipzig University Hospital, 04103 Leipzig, Germany.
Medicines (Basel, Switzerland)
|October 24, 2025
概括
一个检查清单显著改善了急诊室的不良药物反应 (ADR) 识别,发现6.0%的病例,而常规护理中的病例为2.4%. 实施此清单可以通过更好地检测ADR来提高患者的安全性.
科学领域:
- 药物监督 药物监督 药物监督
- 紧急医疗 紧急医疗
- 临床药理学 临床药理学
背景情况:
- 紧急诊所 (ED) 处理各种患者投诉,药物不良反应 (ADR) 是潜在的潜在原因.
- 在ED中准确识别ADR对于优化药物治疗和防止患者受到伤害至关重要.
- 忽视的副作用可能会导致严重后果,需要改进检测方法.
研究的目的:
- 评估基于检查清单的方法的有效性,以确定ADR作为ED呈现的原因.
- 为了比较ADR识别率在检查清单方法和常规医生文件之间的ED.
- 通过系统性审查评估改善ADR检测的潜力.
主要方法:
- 对于向ED提交的患者的医疗记录的回顾性分析.
- 两个评估阶段: (1) 独立检查员使用预定义的检查清单进行评估,并 (2) 审查ED医生记录的ADR.
- 使用McNemar测试分析ADR识别中的差异的统计比较.
主要成果:
- 在34,747名被评估的患者中,一个检查清单确定了2071 (6.0%) 的副作用是ED访问的原因.
- 勃起障碍医生仅在828名 (2.4%) 患者中记录了不良反应.
- 与常规护理相比,检查清单方法显著改善了ADR识别 (6.0%对2.4%,p < 0.001).
- 恶化的一般状况是最常见的首要投诉,而抗血栓剂是最常见的药物类别,与ADR有关.
结论:
- 在常规的ED护理中,ADRs经常被忽视,这可以通过使用检查清单的更高检测率来证明.
- 在常规ED过程中实施基于检查清单的方法可以显著提高ADRs的识别.
- 改进ADR检测有潜力优化药物治疗,防止患者受到伤害.
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