在HHV-8相关的多中心卡斯特曼病的诊断挑战在一个患者之前卡波西肉瘤
Seraphima S Sidhom1, Luke A Laconi1, Christopher A LaFond1,2
1Michigan State University College of Human Medicine, Grand Rapids, MI 49503, USA.
Dermatopathology (Basel, Switzerland)
|October 24, 2025
概括
人类疹病毒-8 (HHV-8) 相关的多中心卡斯特曼病 (MCD) 是一种罕见的疾病. 早期诊断和切除活检对于治疗卡波西肉瘤患者的MCD至关重要.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 人类疹病毒-8 (HHV-8) 相关的多中心卡斯特曼病 (MCD) 是一种罕见的淋巴增殖性疾病.
- 它带来了诊断挑战,特别是在艾滋病毒和卡波西肉瘤 (KS) 的免疫功能低下个体中.
研究的目的:
- 报告一个具有挑战性的HHV-8相关的MCD病例,该病例发生在KS的HIV阳性患者身上.
- 强调切除活检的诊断效用和利图西马布治疗的有效性.
主要方法:
- 一个68岁的艾滋病毒感染者和KS的男性病例报告,呈现出宪法症状和淋巴腺病变.
- 诊断评估包括实验室检测,成像,核心淋巴结活检和切除淋巴结活检.
- 治疗包括Rituximab单一治疗.
主要成果:
- 患者呈现出发烧,夜间出汗,体重减轻,疲劳,淋巴腺病,壮症和新的皮肤病变.
- 核心活检是非诊断性的;切除活检揭示了与HHV-8相关的MCD的特征特征.
- 利图西马布治疗导致临床改善和症状消失.
结论:
- 在有新的系统性或皮肤性发现的KS患者中,对MCD的高怀疑指数至关重要.
- 切除活检对于诊断MCD是有价值的,当核心活检是不确定的.
- 利图西马布是一种有效的治疗HHV-8相关的MCD.
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