孕产妇的低度炎症和女儿的神经性厌食症的风险
Emma Saure1, Pyry N Sipilä2, Cynthia M Bulik3,4,5
1Department of Psychiatry, Division of Adolescent Psychiatry, Helsinki University Hospital, Helsinki, Finland.
The International journal of eating disorders
|October 24, 2025
概括
怀孕期间由高敏感性C反应蛋白 (hs-CRP) 表示的孕产妇炎症与女儿神经性厌食症 (AN) 的风险增加无关. 相反,较低的孕产妇炎症与较高的AN风险有关.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 精神病学是一个精神病学.
背景情况:
- 产前暴露可能会影响神经和代谢发育,可能会影响饮食障碍的风险.
- 高灵敏度C反应蛋白 (hs-CRP) 是炎症的一个关键生物标志物.
研究的目的:
- 调查母亲妊娠hs-CRP水平与女儿患神经性厌食症 (AN) 的风险之间的关联.
主要方法:
- 一个嵌套的病例控制研究使用了芬兰基于登记册的队列.
- 包括150名女性AN患者,年龄和性别匹配的人口对照,以及生物姐妹对照.
- 采用同胞比较设计进行可靠的分析.
主要成果:
- 与姐妹对照组相比,较高的母体hs-CRP与AN风险降低有关 (aOR为0.68).
- 与姐妹 (aOR 0.35) 和所有对照组 (aOR 0.52) 相比,母亲hs-CRP的最高三位数显示AN风险显著降低.
结论:
- 没有证据表明更高的妊娠hs-CRP增加了AN风险.
- 在怀孕早期,较低的母性低度炎症与女儿AN风险增加有关.
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