怀孕相关黑色素瘤流行病学:一个多中心的欧洲研究
Maria Kostaki1, Michaela Plaka2, Vasiliki Chardalia2
1General Hospital of Athens G. Gennimatas, Plastic Surgery, Microsurgery Burns and Melanoma Referral Center, Athens, Greece.
概括
怀孕相关的黑色素瘤 (PAM) 影响年轻女性,经常在现有的上发展. 然而,怀孕并不会使黑色素瘤的预后恶化,5年无复发存活率为95%.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 生殖健康 生殖健康
背景情况:
- 全球范围内黑色素瘤的发病率正在上升,怀孕期间的发病率在增加.
- 关于产后早期黑色素瘤的研究有限.
- 怀孕相关黑色素瘤 (PAM) 是怀孕期间最常见的恶性瘤.
研究的目的:
- 描述PAM的流行病学和临床病理学特征.
- 为了比较PAM特征与与怀孕无关的黑色素瘤.
主要方法:
- 一项多中心欧洲研究确定了1270名年龄在15-49岁的女性被诊断患有黑色素瘤 (2012-2022年).
- 70例 (5.5%) 被归类为PAM.
- 在PAM和非PAM组之间的临床和组织病理特征的比较.
主要成果:
- 与非PAM患者相比,患有PAM的女性更年轻 (平均年龄35.7岁),并且瘤较多.
- 大多数PAM是表面传播的 (80.0%),平均Breslow厚度为1.16毫米.
- 非PAM瘤显示瘤透淋巴细胞 (TILs) 的密度明显更高,这表明免疫反应更强.
结论:
- 怀孕似乎不会对黑色素瘤预后产生负面影响.
- PAM表现出明显的临床特征,需要进一步研究.
- 提高对怀孕期间可疑病变的认识和皮肤学评估至关重要,因为在先前存在的 nevi 上经常发生PAM.
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