在不同程度的慢性食道炎中,背景粘膜的遗传变异
Takuya Ohashi1, Kenichiro Okimoto1, Tatsuya Kaneko1
1Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Journal of gastroenterology and hepatology
|October 24, 2025
概括
无论病变的程度如何,TP53基因突变都会在患有食道状细胞癌 (ESCC) 或状张症 (SD) 的慢性食道炎患者的背景粘膜中积累. 定期内镜监测对于早期ESCC检测至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 慢性食道炎带有可变的癌症风险,受卢戈尔的空化病变 (LVLs) 的影响.
- 在患有食道状细胞癌 (ESCC) 或状形 (SD) 病史的患者中,与LVLs等级相关的背景粘膜的遗传景观仍然未得到充分探索.
研究的目的:
- 根据LVLs等级,研究背景食道粘膜的遗传特征.
- 为了比较ESCC或SD的内镜治疗史患者的基因突变模式.
主要方法:
- 34名患者 (28名ESCC,6名SD) 根据LVLs等级进行了分层.
- 从ESCC/SD和背景粘膜的内镜活检中提取了DNA.
- 使用食道癌面板确定了体性突变,并通过OncoKB.B.确定了假定的驱动因素.
主要成果:
- 与背景粘膜相比,TP53突变在LVL中明显更为普遍 (88.2%与64.7%相比).
- 包括假定驱动因素在内的NOTCH1突变在背景粘膜中比ESCC/SD更为频繁 (82.3%对44.1%).
- 在LVL等级B和C之间没有观察到背景粘膜中TP53或NOTCH1驱动突变的显著差异.
结论:
- 在患有ESCC或SD的慢性食道炎患者的背景粘膜中,无论LVL级别如何,都会积累TP53突变.
- 患有LVLs级B慢性食道炎的患者需要定期进行内镜监测,以便及时检测ESCC.
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