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在活性中性粒体上可转化单的In Situ组装通过破坏NE核转位来减轻NETs诱导的肝细胞癌转移

Yichi Chen^1,2, Yijun Wang¹, Haitao Shang^2,3

¹Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|October 24, 2025

概括

一种新型的性纳米材料 (FTP-NP) 通过向中性粒细胞膜上的中性粒细胞弹性酶 (NE),有效地抑制中性粒细胞外细胞陷 (NET) 的形成和转移,提供了有前途的癌症治疗方法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米医学是一种纳米医学.

背景情况:

中性粒细胞外细胞陷 (NETs) 促进瘤转移.
中性粒细胞弹性酶 (NE) 转位是NETs形成的关键.
向NE对于抑制NETs介导的转移至关重要.

研究的目的:

开发一种基于纳米材料的策略,以抑制NETs形成和HCC转移.
研究FTP-NP在调节NE亚细胞局部化的作用机制.
在临床前模型中评估FTP-NP的治疗疗效.

主要方法:

开发一种性纳米材料 (FTP-NP),可以将NE与活性中性粒细胞膜结合.
在FTP-NP的现场纤维转化形成NE纤维集群.
在体外和体内实验,包括单细胞RNA测序 (scRNA-seq).

主要成果:

FTP-NP 形成 NE 纤维集群,使 NE 失活,并促进其传输到细胞膜.
NE-纤维细胞集群作为物理屏障,防止NET粘附于瘤细胞.
FTP-NP显著减少了NETs的形成,转移负担,并增强了抗瘤免疫力.

结论:

对于NETs介导的瘤转移,FTP-NP提供了一种精确和局部化的治疗方法.
与传统的抑制剂相比,这种策略最大限度地减少了非目标效应和全身毒性.
NE-纤维细胞集群代表了对抗瘤转移的创新治疗策略.

关键词:

肝细胞癌转移的转移.在活体内组装.中性粒细胞弹性酶.中性粒细胞外细胞陷可转化的可转化.

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