在生物活性玻尿酸玻璃中的双重结构作用调节生物活性,细胞相容性和静血潜力
Mariana Sversut Gibbin1,2, Vitor Santaella Zanuto1, Jose G Munguia-Lopez2,3
1Departamento de Física, Universidade Estadual de Maringá, Maringá, PR 87020-900, Brazil.
ACS applied materials & interfaces
|October 24, 2025
概括
玻酸盐玻璃中的氧化 (Nb2O5) 作为网络前体和修饰剂,影响结构,反应性和生物性能. 这种双重作用允许为生物医学应用量身定制生物活性玻璃特性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 玻璃化学 玻璃化学
背景情况:
- 设计生物活性玻璃需要了解组成如何影响结构-属性关系.
- 网络修饰器在调整特定应用的玻璃行为方面发挥着至关重要的作用.
研究的目的:
- 调查氧化 (Nb2O5) 加入对化玻璃的结构和多功能生物性能的影响.
- 阐明Nb在酸盐玻璃中的双重结构作用及其对材料性能的影响.
主要方法:
- 酸盐玻璃的合成含有不同Nb2O5含量 (0-10 wt%).
- 使用物理,热和振动技术进行全面的表征.
- 评估表面反应性,离子释放,碳酸 apatite 形成,细胞相容性和静血潜力.
主要成果:
- Nb2O5在<=5 wt%的度下作为网络前体,在更高度下作为修饰剂,改变玻璃网络连接性.
- 纳入Nb影响了硬度,弹性模量,表面反应性和离子释放.
- 含有Nb的眼镜显示维持或增强细胞相容性,但降低了静血潜力.
结论:
- 酸盐玻璃中Nb的双重结构作用为生物医学应用量身定制多功能性质提供了一个策略.
- 了解Nb的影响,为设计先进的生物活性材料提供了洞察力.
- 结合Nb调节了诸如生物活性和细胞相互作用等关键性质.
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