春尾草 (Folsomia candida) 对短链和多化物质的多代反应
Ge Xie1, Michiel H S Kraak2, J Arie Vonk2
1Amsterdam Institute for Life and Environment, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Environmental toxicology and chemistry
|October 24, 2025
概括
短链化物和多化物 (PFAS) 对土壤有机体构成风险. perfluorobutane sulfonamide (FBSA) 在几代人中对春尾动物表现出显著的繁殖毒性,与 perfluorobutane sulfonic acid (PFBS) 不同.
科学领域:
- 环境科学 环境科学
- 生态毒理学 生态毒理学
- 土壤生物学 土壤生物学
背景情况:
- 短链化物和多化物 (PFAS) 是普遍存在的环境污染物.
- PFAS对土壤生物的慢性,多代毒性影响尚不清楚.
- 调查特定的PFAS,如PFBS和FBSA对关键的土壤无脊椎动物的影响对于风险评估至关重要.
研究的目的:
- 评估 perfluorobutane sulfonic acid (PFBS) 和其前体 perfluorobutane sulfonamide (FBSA) 对土壤的多代毒性,这些毒性是源尾虫 (Folsomia candida) 的.
- 为了确定中位数致命度 (LC50) 和中位数效应度 (EC50) 的生殖 (EC50_repro) 和人口增长率 (EC50_r).
- 为了比较PFBS和FBSA在五个连续世代的相对毒性.
主要方法:
- 在干燥的土壤中,Folsomia candida 暴露于五代 PFBS 和 FBSA 的不同度.
- 量化成人生存率 (LC50),生殖产量 (EC50_repro) 和人口增长率 (EC50_r) 作为毒性终点.
- 对毒性数据的统计分析,包括计算EC50值的95%置信区间.
主要成果:
- perfluorobutane sulfonic acid (PFBS) 的毒性较低,LC50和EC50_r超过了所有代的最高测试度 (1,300 mg/kg).
- perfluorobutane sulfonamide (FBSA) 具有显著的生殖毒性,EC50_repro值远低于PFBS,特别是在早期代 (F0和F1) 中.
- FBSA对F. candida繁殖的毒性是PFBS的1,140倍以上,突出了前体化合物带来的更大的风险.
结论:
- 缺乏研究的PFAS,如FBSA,由于明显的生殖毒性,可能对土壤生态系统构成重大隐患.
- 多代危险评估对于准确捕捉PFAS等持久化学品的潜在风险至关重要.
- 环境风险评估应扩大PFAS化合物的范围,包括前体和研究较少的短链变体.
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