合作的微生物代谢增强了秋季军虫中托介导的杀虫剂排毒
Yunhua Zhang1,2,3, Wujia Mo1, Keyi Chen1
1Zhejiang Provincial Key Laboratory of Intelligent Low-Carbon Biosynthesis, Research Center for Industries of the Future, School of Engineering, Westlake University, Hangzhou, Zhejiang 310030, China.
The ISME journal
|October 24, 2025
概括
肠道微生物Enterococcus casseliflavus EMBL-3帮助秋季军通过产生对排毒至关重要的托芬来抵抗杀虫剂. 这突显了微生物组介导的排毒是抗农药害虫的关键漏洞.
科学领域:
- 农业科学 农业科学
- 微生物学 微生物学
- 昆虫生理学 昆虫生理学
背景情况:
- 秋季军虫 (Spodoptera frugiperda) 是一个重要的农业害虫,具有快速发展的抗昆虫剂耐药性.
- 虽然宿主遗传学起着作用,但肠道共生体对抗虫剂耐药性的贡献尚不清楚.
研究的目的:
- 调查肠道共生体介导的代谢途径在秋季军中产生抗虫剂的作用.
- 阐明共生生物对中的抗性有所贡献的具体机制.
主要方法:
- 代谢学和同位素追踪被用来确定微生物的代谢贡献.
- 使用CRISPR/Cas9基因编辑来确认特定酶的作用.
- 对三方共生体-宿主代谢网络的分析.
主要成果:
- 杆菌 (Enterococcus casseliflavus EMBL-3) 补偿了饮食中托缺乏的情况,而托是兰利醇耐药性的关键因素.
- 在EMBL-3中,酸被转化为酸,从而激活酸碳水化合物受体.
- 这导致了UDP-glucuronosyltransferase的上调,这是一个关键的解毒酶.
结论:
- 一个层次的共生宿主代谢网络,涉及EMBL-3,酸和UDP-glucuronosyltransferase,驱动着兰利醇耐药性.
- 针对微生物代谢节点提供了一种新的策略,以破坏害虫适应能力和克服抗虫剂耐药性.
- 微生物组介导的排毒代表了抗农药昆虫的普遍脆弱性.
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