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静脉注射利多卡因治疗桃体切除术后儿童的术后疼痛:一项双盲,随机,安慰剂控制的试验
Hubert A Benzon1, Michael R King1, Keith J Kilner1
1From the Department of Anesthesiology.
Anesthesia and analgesia
|October 24, 2025
概括
静脉注射利多卡因在小儿桃体切除术后没有减少疼痛或阿片类药物的使用. 这项研究发现,在接受这种常见手术的儿童中,使用利多卡因输注没有临床益处.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 疼痛管理 疼痛管理
- 术后恢复 术后恢复
背景情况:
- 桃体切除术是一种频繁的儿科手术,具有显著的术后疼痛.
- 目前文献缺乏关于静脉注射利多卡因对儿童桃体切除术后疼痛的疗效的研究.
研究的目的:
- 评估静脉注射利多卡因在减少儿科患者桃体切除术后疼痛的有效性.
主要方法:
- 一个前性,随机,双盲试验,涉及4-10岁的儿童进行桃体切除术.
- 参与者在手术期间和手术后接受了静脉注射利多卡因输液或盐水安慰剂.
- 主要结局是麻醉后护理单位 (PACU) 的阿片类药物消费 (MME).
主要成果:
- 在利多卡因和盐水组之间,PACU吗啡消耗 (MME/kg) 没有显著差异.
- 在疼痛评分 (CHEOPS),激动 (PAED) 或术后恶心/吐方面没有显著差异.
- 家长报告的疼痛和在家中使用药物的情况在各组之间也相似.
结论:
- 术后静脉注射利多卡因输液在儿科桃体切除术中的疼痛管理方面没有显示出临床益处.
- 对儿童非阿片类药物止痛策略的进一步研究是有必要的,基于成年人研究的成功.
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