目标重大抑郁症检测:对诊断生物标志物的系统审查和元分析
Zain-Ul-Abideen Gulbaz1, Shaper Mirza2, Sadiq Naveed3,4,5
1Electrical Engineering Department, Lahore University of Management Sciences, Lahore, Pakistan.
The Psychiatric quarterly
|October 24, 2025
概括
确定主要抑郁症 (MDD) 的可靠诊断生物标志物至关重要. 这篇综述强调了Interleukin-6,BDNF,皮质醇和TNF-α作为有前途的生物标志物,尽管临床使用需要进一步验证.
科学领域:
- 生物标志物发现发现
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 目前缺乏主要抑郁症 (MDD) 的可靠诊断生物标志物.
- 目前对MDD的诊断方法主要依赖于临床观察和主观标准.
研究的目的:
- 系统地审查和量化MDD在体液中的有前途的诊断生物标志物.
- 确定具有临床应用潜力的生物标志物,用于诊断严重抑郁症.
主要方法:
- 从2013年到2023年进行全面的电子文献搜索 (PubMed,PsycINFO,ScienceDirect,谷歌学者)
- 包括对成年人类参与者的研究,将MDD患者与使用体液生物标志物的健康对照进行比较.
- 排除对伴随性疾病,动物模型和神经影像研究的研究.
主要成果:
- 从175项研究中确定了MDD的312种诊断生物标志物.
- 介乐-6 (IL-6),脑衍生神经缩因子 (BDNF),皮质醇,C反应蛋白 (CRP) 和瘤坏死因子-α (TNF-α) 是最常见的生物标志物.
- 分析证实IL-6,BDNF,皮质醇和TNF-α与MDD之间存在显著的关联.
结论:
- IL-6,BDNF,皮质醇和TNF-α显示出作为MDD诊断生物标志物的潜力.
- 为了临床实施,在不同人群中进一步验证是必不可少的.
- 未来的研究应该专注于生物标志物面板和标准化的方法来提高MDD诊断准确度.
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