益生菌的潜在抗癌机制:综合性审查
Chao Tang1, Yue Qian1, Shiyao Jia1
1College of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Probiotics and antimicrobial proteins
|October 24, 2025
概括
益生菌通过影响各种生物途径和增强免疫力,显示出有希望的抗癌作用. 本综述详细介绍了它们的机制和癌症治疗的临床证据,强调了未来的研究方向.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 癌症是全球主要的健康挑战,由于生活方式和环境因素,癌症发病率越来越高.
- 开发有效的,低副作用的癌症疗法是一个至关重要的未满足的需求.
- 益生菌正在成为一种可行的策略,因为它们已证明具有抗瘤特性.
研究的目的:
- 综合审查益生菌的抗癌机制.
- 总结支持益生菌在癌症治疗中的临床证据.
- 讨论未来的前景,包括安全性和菌株特异性影响.
主要方法:
- 对详细说明益生菌抗癌作用的细胞和动物实验的审查.
- 关于益生菌用于癌症治疗的临床试验数据的汇编.
- 关于益生菌对信号通路,细胞亡和免疫的影响的科学文献分析.
主要成果:
- 益生菌通过多种机制产生抗癌作用,包括阻断信号通路,诱导亡,调节肠道微生物群.
- 它们增强抗瘤免疫力,减少炎症,并可以提高传统癌症治疗的疗效.
- 临床证据表明潜在的益处,尽管需要进一步的研究.
结论:
- 益生菌为癌症预防和治疗提供了一个有希望的途径,它具有多种不同的抗瘤机制.
- 对安全性,局限性和菌株特异性的进一步调查对于优化其临床应用至关重要.
- 益生菌是一种新的策略,可以补充现有的癌症疗法.
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Microorganisms in Medicine and Therapeutics
908
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
908
Drugs that Stabilize Microtubules
2.6K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.6K
Drugs that Destabilize Microtubules
3.6K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.6K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Cancer Vaccines
917
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
917


