确定临床上有意义的变化:在患有帕金森病的老年人中,对于常见的抑郁症尺度的最小临床重要差异
Hossein Soltaninejad1, Ghorban Taghizadeh2, Negin Eissazade3,4
1Department of Occupational Therapy School of Rehabilitation Sciences, Arak University of Medical Sciences, Arak, Iran.
Aging clinical and experimental research
|October 24, 2025
概括
这项研究确定了帕金森病 (PD) 中抑郁症尺度的临床重要差异 (MCID) 值. 这些发现有助于评估患有抑郁症的PD患者的治疗有效性.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 老年学是一门学科.
背景情况:
- 最小临床重要差异 (MCID) 量化了患者感知到的最小的有益症状变化.
- 对于帕金森病 (PD) 症状,MCID值已确立,但对于PD中的抑郁症未得到充分研究.
研究的目的:
- 确定贝克抑郁症目录 (BDI-II),医院焦虑和抑郁量表 - 抑郁症分量表 (HADS-D) 和PD患者老年抑郁量表 (GDS-15) 的MCID值.
- 在帕金森病中建立抑郁症评估的基准.
主要方法:
- 112名患有PD和抑郁症的人接受了为期10周的认知行为治疗计划.
- 使用基于分布和基于的方法估计了MCID值,以全球变化评级 (GRoC) 规模为.
主要成果:
- 对于BDI-II,MCID值 (平均差异方法) 为-5.79,HADS-D为-3.52,GDS-15为-3.05 (p < 0.001).这些值均为BDI-II,HADS-D为-3.52,GDS-15为-3.05 (p < 0.001).
- 最佳的MCID切线 (尤登指数) 为BDI-II≤-3,HADS-D≤-2,GDS-15≤-2,显示出高灵敏度和特异性.
结论:
- 这项研究为帕金森病的抑郁症尺度提供了基本的MCID值.
- 这些基准将加强临床决策和对PD抑郁症的干预评估.
相关概念视频
Depressive Disorders: MDD and Dysthymia
547
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
547
Pharmacodynamics in Geriatric Patients: Effects of Age
172
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
172
Parkinson's Disease: Treatment
931
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
931
Parkinson's Disease: Overview
1.7K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.7K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
214
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
214
Drug Dosing: Geriatric Patients
199
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
199


