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移植脏后尿道感染:一些中心比其他中心做得更好
Dominic Amara1, Arielle Grieco2, David Foley3
1Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.
Clinical transplantation
|October 24, 2025
概括
接受移植的人在不同中心的尿路感染 (UTI) 发生率不同. 虽然支架使用和导管持续时间等因素有助于,但尿路感染风险仍然存在显著的中心特异性变化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 传染病流行病学 传染病流行病学
背景情况:
- 尿路感染 (UTI) 是移植后的常见并发症,导致发病率增加和医疗费用增加.
- 怀疑脏移植中心之间的尿路感染率存在显著的变化,但没有得到很好的量化.
研究的目的:
- 调查移植中心30天尿路感染发病率的变化.
- 确定与移植后尿路感染相关的患者特异性和中心特异性因素.
主要方法:
- 来自NSQIP移植试点数据库 (3/2017-7/2020) 的脏移植接受者的分析.
- 利用多变量和层次逻辑回归来识别尿路感染风险因素并评估中心异常状态.
主要成果:
- 在25个中心的5128名接受者中,30天的整体尿路感染发病率为6.1%,未经调整的发病率在0%至12.9%之间.
- 尿路感染的独立风险因素包括尿路支架的使用,尿导管持续时间较长,女性性别和接受者的年龄.
- 这些因素解释了中心变化的17%;经过调整后,三个中心仍然是异常值.
结论:
- 在美国移植中心中,早期尿路感染发病率存在很大差异.
- 已知的风险因素并不能完全解释观察到的尿路感染率的中心水平差异.
- 需要进一步的研究和中心间的合作,以减少移植后的尿路感染.
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