在评估心脏功能障碍时,脂肪肝诊断标准的比较:一个横截面研究
Yun Kyung Cho1,2, Myung Jin Kim1,2, Eun Hee Kim3
1Department of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Hepatology international
|October 24, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MAFLD) 标准比与代谢功能障碍相关的脂肪性肝病 (MASLD) 标准更好地识别早期心脏功能障碍,特别是左心室透静功能障碍. 鉴定MAFLD与更高的扩张性功能障碍风险有关.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是代谢功能障碍相关的脂肪性肝病 (MAFLD) 的另一种定义.
- 这两种情况都与代谢综合征和心血管并发症有关.
- 在这些患者中早期发现心脏功能障碍对于及时干预至关重要.
研究的目的:
- 为了比较MASLD和MAFLD标准在识别心脏功能受损的个体中的诊断效用.
- 评估MASLD/MAFLD与左心室 (LV) 扩张功能障碍之间的关联.
- 为了确定哪些标准更好地预测早期心脏功能障碍.
主要方法:
- 对794名接受例行健康检查的参与者的横截面研究.
- 使用腹部超声学诊断脂肪肝疾病.
- 评估心脏功能,包括透心功能,通过 transthoracic 心脏回声学.
主要成果:
- 在34.3%的参与者中发现了MASLD,在36.3%的参与者中发现了MAFLD.
- 无论是MASLD还是MAFLD都与扩张功能受损有关 (较低的E波/E/A比率,较高的LA直径/A波/E/E'比率).
- 根据MAFLD标准,与MASLD (10.9%) 相比,LV透析功能障碍的风险显著更高 (24.2%). MAFLD的存在独立地增加了 LV 扩张功能障碍风险的 2.857 倍.
结论:
- 无论是MAFLD还是MASLD的标准都与LV的扩张功能障碍有关.
- MAFLD标准在反映一般健康人群中早期心脏功能障碍方面表现出卓越的准确性.
- 在临床实践中采用MAFLD标准可能会增强心血管风险分层和早期干预策略.
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