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Updated: Jan 6, 2026

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TMEM175 不能作为一种质子选择性离子通道来防止溶酶体过度酸化

Erika Riederer1, Vedrana Mikusevic2, Tuoxian Tang1

  • 1Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

The Journal of cell biology
|October 24, 2025
PubMed
概括

与之前的建议相反,TMEM175不是溶酶体中的质子通道. 这种与帕金森病相关的蛋白质导电离子,影响 lysosomal pH,并为疾病机制提供了新的见解.

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