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Updated: Jan 14, 2026

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设计,优化和开发具有改善药理动力学和药理动力学特性的RIPK1降解剂

Dong Lu1, Xin Yu1,2, Hanfeng Lin1,2

  • 1Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.

Journal of medicinal chemistry
|October 24, 2025
PubMed
概括

研究人员开发了LD5097,一种新型化合物,可降解受体相互作用蛋白激酶1 (RIPK1). 这种向降解通过改善临床前模型中的药物特性和疗效来增强癌症免疫疗法.

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